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Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation

30 Aug 2023

Abstract excerpt

Although mouse models are widely used in retinal drug development, pharmacokinetics in mouse eye is poorly understood. In this study, we applied non-invasive in vivo fluorophotometry to study pharmacokinetics of intravitreal fluorescein sodium (molecular weight 0.38 kDa) and fluorescein isothiocyanate-dextran (FD-150; molecular weight 150 kDa) in mice. Intravitreal half-lives of fluorescein and FD-150 in mouse...

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Identifiers

PMID: 37657528
DOI: 10.1016/j.exer.2023.109638

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