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Article

Unraveling the impact of ORF3a Q57H mutation on SARS-CoV-2: insights from molecular dynamics.

Journal of biomolecular structure & dynamics - 1 Nov 2024

Islam Md Jahirul, Alom Md Siddik, Hossain Md Shahadat, Ali Md Ackas, Akter Shaila, Islam Shafiqul, Ullah M Obayed, Halim Mohammad A

Abstract excerpt

ORF3a is a conserved accessory protein of SARS-CoV-2, linked to viral infection and pathogenesis, with acquired mutations at various locations. Previous studies have shown that the occurrence of the Q57H mutation is higher in comparison to other positions in ORF3a. This mutation is known to induce conformational changes, yet the extent of structural alteration and its role in the viral adaptation process remain...

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Identifiers

PMID: 37649361
DOI: 10.1080/07391102.2023.2252908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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