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Article

Structural and functional effects of the L84S mutant in the SARS-COV-2 ORF8 dimer based on microsecond molecular dynamics study.

Journal of biomolecular structure & dynamics - 1 Jul 2024

Islam Shafiqul, Parves Md Rimon, Islam Md Jahirul, Ali Md Ackas, Efaz Faiyaz Md, Hossain Md Shahadat, Ullah M Obayed, Halim Mohammad A

Abstract excerpt

The L84S mutation has been observed frequently in the ORF8 protein of SARS-CoV-2, which is an accessory protein involved in various important functions such as virus propagation, pathogenesis, and evading the immune response. However, the specific effects of this mutation on the dimeric structure of ORF8 and its impacts on interactions with host components and immune responses are not well understood. In this...

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PMID: 37403295
DOI: 10.1080/07391102.2023.2228919

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