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Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer.

Gut microbes - 1 Dec 2023

Gao Wenxing, Gao Xiang, Zhu Lixin, Gao Sheng, Sun Ruicong, Feng Zhongsheng, Wu Dingfeng, Liu Zhanju, Zhu Ruixin, Jiao Na

Abstract excerpt

Microbial signatures show remarkable potentials in predicting colorectal cancer (CRC). This study aimed to evaluate the diagnostic powers of multimodal microbial signatures, multi-kingdom species, genes, and single-nucleotide variants (SNVs) for detecting precancerous adenomas. We performed cross-cohort analyses on whole metagenome sequencing data of 750 samples via xMarkerFinder to identify adenoma-associated...

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Identifiers

PMID: 37635357
DOI: 10.1080/19490976.2023.2245562
PMCID: PMC10464540

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