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Article

Discovering the mechanism of action of drugs with a sparse explainable network.

EBioMedicine - 1 Sept 2023

Sada Del Real Katyna, Rubio Angel

Abstract excerpt

BACKGROUND: Although Deep Neural Networks (DDNs) have been successful in predicting the efficacy of cancer drugs, the lack of explainability in their decision-making process is a significant challenge. Previous research proposed mimicking the Gene Ontology structure to allow for interpretation of each neuron in the network. However, these previous approaches require huge amount of GPU resources and hinder its...

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Identifiers

PMID: 37633093
DOI: 10.1016/j.ebiom.2023.104767
PMCID: PMC10474372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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