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CD1D knockout swine are permissive to African swine fever virus genotype II infection.

Emerging microbes & infections - 1 Dec 2026

Madden Daniel, Trujillo Jessie D, Elango Shanmugasundaram, Fitz Isaac, McDowell Chester D, Assato Patricia, Lyoo Eulim, Kwon Taeyong, Cool Konner, Li Yonghai, Ferreyra Franco Matias, Gaudreault Natasha N, Morozov Igor, Lee Kiho, Driver John, Richt Juergen A

Abstract excerpt

African swine fever virus (ASFV) is an important pathogen of domestic and wild suids and the causative agent of African swine fever (ASF). ASFV displays a tropism for myeloid cells, predominately of the monocyte/macrophage lineage, which is critical for ASFV pathogenesis. However, the mechanisms that govern the cellular tropism of ASFV are complex and incompletely understood. ASFV can enter susceptible cells...

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African Swine Fever
African Swine Fever Virus
Antigens, CD1d
CRISPR-Cas Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Knockout Techniques

Virus Replication

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Open in PubMed Open full text

Identifiers

PMID: 42101028
DOI: 10.1080/22221751.2026.2671519
PMCID: PMC13215427

Genes

CD1D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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