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Article

Increased expression of human antiviral protein MxA in FUS proteinopathy in amyotrophic lateral sclerosis.

Brain pathology (Zurich, Switzerland) - 1 Mar 2024

Honda Hiroyuki, Yagita Kaoru, Arahata Hajime, Hamasaki Hideomi, Noguchi Hideko, Koyama Sachiko, Sasagasako Naokazu

Abstract excerpt

FUS mutations are one of the major mutations in familial amyotrophic lateral sclerosis (ALS). The pathological hallmark is FUS-positive neuronal cytoplasmic inclusions (FUS-NCI), known as FUS proteinopathy. Human myxovirus resistance protein 1 (MxA) is an IFN-induced dynamin-like GTPase that acts as antiviral factor. In this study, we examined the expression of MxA in neurons bearing FUS-NCI. We performed...

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Identifiers

PMID: 37586842
DOI: 10.1111/bpa.13191
PMCID: PMC10901610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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