Article
Archived rilpivirine-associated resistance mutations among ART-naive and virologically suppressed people living with HIV-1 subtype C in Botswana: implications for cabotegravir/rilpivirine use.
The Journal of antimicrobial chemotherapy - 3 Oct 2023
Maruapula Dorcas, Moraka Natasha O, Bareng Ontlametse T, Mokgethi Patrick T, Choga Wonderful T, Seatla Kaelo K, Kelentse Nametso, Koofhethille Catherine K, Zuze Boitumelo J L, Gaolathe Tendani, Pretorius-Holme Molly, Makhema Joseph, Novitsky Vlad, Shapiro Roger, Moyo Sikhulile, Lockman Shahin, Gaseitsiwe Simani
Abstract excerpt
OBJECTIVES: Pre-existing rilpivirine resistance-associated mutations (RVP-RAMs) have been found to predict HIV-1 virological failure in those switching to long-acting injectable cabotegravir/rilpivirine. We here evaluated the prevalence of archived RPV-RAMs in a cohort of people living with HIV (PWH). METHODS: We analysed near full-length HIV-1 pol sequences from proviral DNA for the presence of RPV-RAMs, which...
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