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Article

Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort.

Aging cell - 1 Oct 2023

Chen Jiachen, Doyle Margaret F, Fang Yuan, Mez Jesse, Crane Paul K, Scollard Phoebe, Satizabal Claudia L, Alosco Michael L, Qiu Wei Qiao, Murabito Joanne M, Lunetta Kathryn L

Abstract excerpt

Inflammatory protein biomarkers induced by immune responses have been associated with cognitive decline and the pathogenesis of Alzheimer's disease (AD). Here, we investigate associations between a panel of inflammatory biomarkers and cognitive function and incident dementia outcomes in the well-characterized Framingham Heart Study Offspring cohort. Participants aged ≥40 years and dementia-free at Exam 7 who had...

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Identifiers

PMID: 37584418
DOI: 10.1111/acel.13955
PMCID: PMC10577533

Genes

APOE
CCL19
CDCP1
IL10
LIF

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