Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.

International journal of cancer - 1 Jan 2024

Constantinescu Andrei-Emil, Bull Caroline J, Jones Nicholas, Mitchell Ruth, Burrows Kimberley, Dimou Niki, Bézieau Stéphane, Brenner Hermann, Buchanan Daniel D, D'Amato Mauro, Jenkins Mark A, Moreno Victor, Pai Rish K, Um Caroline Y, White Emily, Murphy Neil, Gunter Marc, Timpson Nicholas J, Huyghe Jeroen R, Vincent Emma E

Abstract excerpt

Observational studies have suggested a protective role for eosinophils in colorectal cancer (CRC) development and implicated neutrophils, but the causal relationships remain unclear. Here, we aimed to estimate the causal effect of circulating white blood cell (WBC) counts (N = ~550 000) for basophils, eosinophils, monocytes, lymphocytes and neutrophils on CRC risk (N = 52 775 cases and 45 940 controls) using...

Topics

Join the communities discussing this publication.

Colorectal Neoplasms
Eosinophils
Genome-Wide Association Study
Leukocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 37578112
DOI: 10.1002/ijc.34691
PMCID: PMC10864681

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating white blood cell traits and colorectal cancer risk: A Mendelian randomisation study.PMID 37578112Read ↗

Prospective Mendelian Randomization Study of Ancestry-Specific Blood-Cell Genetics in Predicting Pan-Cancer Risk Across 28 Malignant NeoplasmsSemantic proximity Read ↗

Trans-ancestry analysis in over 799,000 individuals yields new insights into the genetic etiology of colorectal cancer.Semantic proximity Read ↗

Prospective study on the association between 36 human blood cell traits and pan-cancer outcomes: a mendelian randomization analysis.Semantic proximity Read ↗

Causal Relationship between Peripheral Immune Cell Counts and Inflammatory Bowel Diseases: A Bi-directional Two-sample Mendelian Randomization StudySemantic proximity Read ↗

White blood cell traits and lung cancer risk: a two-sample mendelian randomization analysis.Semantic proximity Read ↗

To unveil the causal relationship between immunophenotypes and colorectal cancer using two-sample bidirectional Mendelian randomization and mediation analyses.Semantic proximity Read ↗

The Causal Relationship Between White Blood Cells Counts and Hepatocellular Carcinoma: A Mendelian Randomization StudySemantic proximity Read ↗

The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study.Semantic proximity Read ↗

Mendelian randomization analysis of the association between human blood cell traits and uterine polyps.Semantic proximity Read ↗

Causal impacts of 731 immunocyte phenotypes on colorectal cancer-evidence from a bidirectional two-sample Mendelian randomization.Semantic proximity Read ↗

Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.Semantic proximity Read ↗

Mendelian randomisation analyses of eosinophils and other blood cell types in relation to lung function and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.