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FOXP1-GINS1 axis promotes DLBCL proliferation and directs doxorubicin resistance

1 Jan 2023

Abstract excerpt

GINS1 is overexpressed in several types of cancers including leukemia and linked to poor outcomes. However, GINS1 remains poorly investigated in DLBCL (diffuse large B-cell lymphoma). This project aimed to explore the expression, functions and regulation of GINS1 in DLBCL. In this study, through analysis of clinical specimens from DLBCL patients, we uncovered that GINS1 was upregulated in DLBCL. By EMSA, ChIP and...

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PMID: 37576391
DOI: 10.7150/jca.85906

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