Pan-cancer analysis of GINS1 identifies its prognostic and immunotherapy predictive value with in vitro experimental validation in nasopharyngeal carcinoma.

Abstract excerpt

BACKGROUND: GINS complex subunit 1 (GINS1) is part of the tetrameric GINS complex involved in DNA replication, playing a vital role in controlling the start and continuation of DNA replication. Its role in cancer, however, is not well understood. Still, its relevance to cancer is uncertain. This study focused on exploring the role of GINS1 in different forms of cancer. METHODS: Using a range of publicly available...

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• Biomarkers, Tumor
• Cell Line, Tumor
• Cell Proliferation
• Chromosomal Proteins, Non-Histone
• Gene Expression Regulation, Neoplastic