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3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis.

Cancer gene therapy - 1 Oct 2023

Mu Mingchao, Zhang Qin, Zhao Chenye, Li Xiaopeng, Chen Zilu, Sun Xuejun, Yu Junhui

Abstract excerpt

Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide. Cetuximab, in combination with chemotherapy, is effective for treating patients with wild-type KRAS/BRAF metastatic CRC (mCRC). However, intrinsic or acquired drug resistance often limits the use of cetuximab. In this study, we investigated the potential of co-treatment with 3-Bromopyruvate (3-BP) and cetuximab to overcome...

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Antineoplastic Agents
Caco-2 Cells
Cetuximab
Colorectal Neoplasms
Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

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PMID: 37558749
DOI: 10.1038/s41417-023-00648-5
PMCID: PMC10581902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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