Semi-infectious particles contribute substantially to influenza virus within-host dynamics when infection is dominated by spatial structure

Abstract excerpt

Abstract Influenza is an ribonucleic acid virus with a genome that comprises eight segments. Experiments show that the vast majority of virions fail to express one or more gene segments and thus cannot cause a productive infection on their own. These particles, called semi-infectious particles (SIPs), can induce virion production through complementation when multiple SIPs are present in an infected cell. Previous...