Collective interactions augment influenza A virus replication in a host-dependent manner

Abstract excerpt

Infection with a single influenza A virus (IAV) is only rarely sufficient to initiate productive infection. Here, we exploit both single-cell approaches and whole-animal systems to show that IAV reliance on multiple infection can form an important species barrier to infection. Namely, we find that H9N2 subtype viruses representative of those circulating widely at the poultry-human interface exhibit acute dependenc...

Topics

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• Animal Disease Management and Epidemiology
• Genetic Variation
• Influenza A virus
• Influenza, Human
• Influenza Vaccines
• Influenza Virus Research Studies
• Respiratory viral infections research
• RNA and protein synthesis mechanisms

Identifiers and source

Literature Corpus work

d739fa68-4dd4-51c7-b83a-6034fa5d7149

DOI

10.1101/736108