TNFRSF13B gene mutation in familial acute myeloid leukemia: A new piece in the complex scenario of hereditary predisposition?

doi:10.1002/hon.3212

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TNFRSF13B gene mutation in familial acute myeloid leukemia: A new piece in the complex scenario of hereditary predisposition?

Hematological oncology - 1 Dec 2023

Cumbo Cosimo, Orsini Paola, Tarantini Francesco, Anelli Luisa, Zagaria Antonella, Tragni Vincenzo, Coccaro Nicoletta, Tota Giuseppina, Parciante Elisa, Conserva Maria Rosa, Redavid Immacolata, Minervini Crescenzio Francesco, Minervini Angela, Attolico Immacolata, Gentile Mattia, Pierri Ciro Leonardo, Specchia Giorgina, Musto Pellegrino, Albano Francesco

Abstract excerpt

TNFRSF13B mutations are widely associated with common variable immunodeficiency. TNFRSF13B was recently counted among relevant genes associated with childhood-onset of hematological malignancies; nonetheless, its role in acute myeloid leukemia (AML) remains unexplored. We report the study of a family with two cases of AML, sharing a germline TNFRSF13B mutation favoring the formation of a more stable complex with...

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PMID: 37534633
DOI: 10.1002/hon.3212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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