ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.

doi:10.1016/j.modpat.2023.100294

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Article

ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2023

Meredith David M, Cooley Linda D, Dubuc Adrian, Morrissette Jennifer, Sussman Robyn T, Nasrallah MacLean P, Rathbun Pamela, Yap Kai Lee, Wadhwani Nitin, Bao Liming, Wolff Daynna J, Ida Cristiane, Sukhanova Madina, Horbinski Craig, Jennings Lawrence J, Farooqi Midhat, Gener Melissa, Ginn Kevin, Kam Kwok Ling, Sasaki Koji, Kanagal-Shamanna Rashmi, Alexandrescu Sanda, Brat Daniel, Lu Xinyan

Abstract excerpt

Gliomas harboring oncogenic ROS1 alterations are uncommon and primarily described in infants. Our goal was to characterize the clinicopathological features and molecular signatures of the full spectrum of ROS1 fusion-positive gliomas across all age groups. Through a retrospective multi-institutional collaboration, we report a collection of unpublished ROS1 fusion gliomas along with the characterization and...

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PMID: 37532182
DOI: 10.1016/j.modpat.2023.100294

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