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Article

Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species

2 Aug 2023

Abstract excerpt

Olorofim is a new antifungal in clinical development which has a novel mechanism of action against dihydroorotate dehydrogenase (DHODH). DHODH form a ubiquitous family of enzymes in the de novo pyrimidine biosynthetic pathway and are split into class 1A, class 1B and class 2. Olorofim specifically targets the fungal class 2 DHODH present in a range of pathogenic moulds. The nature and number of DHODH present in...

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PMID: 37531380
DOI: 10.1371/journal.pone.0289441

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