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Biosynthesis of the antifungal haterumalide, oocydin A , in S erratia , and its regulation by quorum sensing, RpoS and Hfq

6 Mar 2015

Abstract excerpt

Polyketides represent an important class of bioactive natural products with a broad range of biological activities. We identified recently a large trans-acyltransferase (AT) polyketide synthase gene cluster responsible for the biosynthesis of the antifungal, anti-oomycete and antitumor haterumalide, oocydin A (ooc). Using genome sequencing and comparative genomics, we show that the ooc gene cluster is widespread...

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PMID: 25753587
DOI: 10.1111/1462-2920.12839

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