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Article

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

1 May 2023

Abstract excerpt

Bacillus Calmette-Guérin (BCG) vaccination is a prototype model for the study of trained immunity (TI) in humans, and results in a more effective response of innate immune cells upon stimulation with heterologous stimuli. Here, we investigate the heterogeneity of TI induction by single-cell RNA sequencing of immune cells collected from 156 samples. We observe that both monocytes and CD8 + T cells show...

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PMID: 37155329
DOI: 10.1016/j.celrep.2023.112487

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