Clinical Implications and Application of Molecular Testing in the Diagnosis and Management of Thyroid Nodules in the Chinese Population.

doi:10.1158/1078-0432.CCR-25-0270

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Article

Clinical Implications and Application of Molecular Testing in the Diagnosis and Management of Thyroid Nodules in the Chinese Population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2025

Ding Min, Wu Gaosong, Zhang Songtao, Xie Rongli, Yuan Jianming, Xiao Guohui, Zhang Xiaoyue, Dai Jiaqi, Chen Jian, Wang Sanming, Zhou Rui, Li Xingchen, Zhao Jiuzhou, Ning Fangzheng, Wu Zeyu, Yin Zhiqiang, Fei Jian

Abstract excerpt

PURPOSE: Ultrasound-guided fine-needle aspiration biopsy is the gold standard for diagnosing thyroid cancer, but 20% to 35% of nodules remain cytologically indeterminate. This study evaluated the value of molecular testing in diagnosing thyroid cancer and its preoperative risk stratification in the Chinese population. EXPERIMENTAL DESIGN: This multicenter observational study included patients with thyroid nodules...

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Topics

Humans
Thyroid Nodule
Male
Female
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

China

Aged

High-Throughput Nucleotide Sequencing

Biopsy, Fine-Needle

Thyroid Neoplasms

Mutation

Biomarkers, Tumor

Proto-Oncogene Proteins B-raf

Young Adult

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 40577541
DOI: 10.1158/1078-0432.CCR-25-0270
PMCID: PMC12666309

Genes

BRAF
CCDC6
RET
TERT

Variants

Provenance

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