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[Application of single-sperm sequencing technology in preimplantation genetic testing for men with autosomal dominant polycystic kidney disease].

Zhonghua nan ke xue = National journal of andrology - 1 May 2022

Deng Tian-Qin, Xie Yu-Li, Zhang Hua-Kun, Chen Hai-Yan, Jiao Shu-Jing, Li Xue-Mei

Abstract excerpt

OBJECTIVE: To investigate the value of single-sperm sequencing technology in preimplantation genetic testing. METHODS: Haplotypes were constructed by single-sperm isolation combined with single-sperm sequencing for a patient with autosomal dominant polycystic kidney disease (ADPKD) caused by de novo mutation of the PKD1 gene c.3815T>G. 50. Single-sperm samples were isolated by mechanical braking, whole-genome...

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PMID: 37477479

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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