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Article

The clinical application of single-sperm-based single-nucleotide polymorphism haplotyping for PGT of patients with genetic diseases.

Reproductive biomedicine online - 1 Jan 2022

Huang Chenyang, Zheng Bo, Chen Linjun, Diao Zhenyu, Zhou Jianjun

Abstract excerpt

RESEARCH QUESTION: Is there a simple and effective method for male patients with genetic disorders in families with no identified haplotype and with Robertsonian translocations to avoid the transfer of embryos carrying translocated chromosomes? DESIGN: Single spermatozoa were separated to identify by next-generation sequencing (NGS) those that were genetically abnormal, to establish a sperm-based...

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PMID: 34862136
DOI: 10.1016/j.rbmo.2021.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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