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Article

SSEA-1 Correlates With the Invasive Phenotype in Breast Cancer.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Aug 2023

Kohler Katharina T, Møller Hansen Anna A, Kim Jiyoung, Villadsen René

Abstract excerpt

The glycan moiety Lewis X (LeX) has been implicated in defining progenitor cells as well as playing a role in the progression of solid tumors, including breast cancer. Here, we used the original stage-specific embryonic antigen-1 (SSEA-1) antibody, MC-480, targeting the LeX motif to examine the expression pattern of this marker within the context of a differentiation hierarchy as well as functional properties of...

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Identifiers

PMID: 37477396
DOI: 10.1369/00221554231189312
PMCID: PMC10424578

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