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Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase ( ALK)

20 Jul 2023

Abstract excerpt

We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in...

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PMID: 37475109
DOI: 10.1111/pcmr.13115

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