Article
Generation of gene corrected human isogenic iPSC lines (IDVi003-A_CR13, IDVi003-A_CR21, IDVi003-A_CR24) from an inherited retinal dystrophy patient-derived IPSC line ITM2B-5286-3 (IDVi003-A) carrying the ITM2B c.782A > C variant using CRISPR/Cas9.
Stem cell research - 1 Sept 2023
Ben Yacoub Tasnim, Letellier Camille, Wohlschlegel Juliette, Condroyer Christel, Slembrouck-Brec Amélie, Goureau Olivier, Zeitz Christina, Audo Isabelle
Abstract excerpt
The ITM2B-related retinal dystrophy (ITM2B-RD) was identified within patients carrying the autosomal dominant variant [c.782A > C, p.(Glu261Ala)] in ITM2B from whom induced pluripotent stem cell (IPSC) lines were previously generated. Here, we report the generation of three isogenic control iPSC lines from the derived affected subject cell line (ITM2B-5286-3) using CRISPR/Cas9 engineering. The three generated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.