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Generation of a gene-corrected human iPSC line (CSUASOi004-A-1) from a retinitis pigmentosa patient with heterozygous c.2699 G>A mutation in the PRPF6 gene.

Stem cell research - 1 Oct 2022

Liang Yuqin, Sun Xihao, Duan Chunwen, Zhou Yalan, Cui Zekai, Ding Chengcheng, Gu Jianing, Mao Shengru, Ji Shangli, Chan Hon Fai, Tang Shibo, Chen Jiansu

Abstract excerpt

Retinitis pigmentosa (RP) is one of the most common inherited retinal diseases characterized by nyctalopia, progressive vision loss and visual field contraction. we previously generated an induced pluripotent stem cell line (CSUASOi004-A) from a RP patient with heterozygous PRPF6 c.2699 G>A (p.R900H) mutation. Here we corrected the PRPF6 c.2699 G>A mutation genetically using CRISPR/Cas9 technology to generate an...

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PMID: 36103774
DOI: 10.1016/j.scr.2022.102911

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Generation of a gene-corrected human iPSC line (CSUASOi004-A-1) from a retinitis pigmentosa patient with heterozygous c.2699 G>A mutation in the PRPF6 gene.PMID 36103774Read ↗

Generation of a gene-corrected isogenic human iPSC line (CSUASOi006-A-1) from a retinitis pigmentosa patient with heterozygous c.5792C > T mutation in the PRPF8 gene.Semantic proximity Read ↗

CRISPR/Cas9-mediated generation of a human induced pluripotent stem cell line with PRPF6 c.2699 G > A mutation to model retinitis pigmentosa.Semantic proximity Read ↗

Establishment of induced pluripotent stem cell line CSUASOi004-A by reprogramming peripheral blood mononuclear cells of a PRPF6-related dominant retinitis pigmentosa patient.Semantic proximity Read ↗

Generation of a human iPSC line from a patient with retinitis pigmentosa caused by mutation in PRPF8 gene.Semantic proximity Read ↗

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Establishment of non-integrate induced pluripotent stem cell line CSUASOi006-A, from urine-derived cells of a PRPF8-related dominant retinitis pigmentosa patient.Semantic proximity Read ↗

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