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Article

Biallelic rescue of CTG18.1 in two Fuchs endothelial corneal dystrophy-derived iPSC lines (SCTCi047-A-2, SCTCi046-A-2) following a two-step gene editing strategy.

Stem cell research - 1 Sept 2026

Landi Elisa, van Beusekom Ellen, Ben-Dor Shifra, Albert Silvia, Dickman Mor M, LaPointe Vanessa L S, van Bokhoven Hans

Abstract excerpt

Fuchs endothelial corneal dystrophy (FECD) is an age-related condition distinguished by the degeneration of the corneal endothelium. An intronic CTG18.1 repeat in the transcription factor 4 (TCF4) gene has been associated with a 78-fold increased risk of developing the disease when at least one copy of the CTG18.1 expands above 50 repeats. Employing patient-derived material, we applied a dual CRISPR/Cas9-mediated...

Read the complete abstract on PubMed

Topics

Humans
Induced Pluripotent Stem Cells
Fuchs' Endothelial Dystrophy
Gene Editing
Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

CRISPR-Cas Systems

Transcription Factor 4

Alleles

Source

Identifiers

PMID: 42314573
DOI: 10.1016/j.scr.2026.104032

Genes

TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Biallelic rescue of CTG18.1 in two Fuchs endothelial corneal dystrophy-derived iPSC lines (SCTCi047-A-2, SCTCi046-A-2) following a two-step gene editing strategy.PMID 42314573Read ↗

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