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Article

Mendelian randomization uncovers a protective effect of interleukin-1 receptor antagonist on kidney function

14 Jul 2023

Abstract excerpt

Interleukins (ILs), key cytokine family of inflammatory response, are closely associated with kidney function. However, the causal effect of various ILs on kidney function needs further investigation. Here we show two-sample summary-level Mendelian randomization (MR) analysis that examined the causality between serum IL levels and kidney function. Genetic variants with strong association with serum IL levels were...

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PMID: 37452175
DOI: 10.1038/s42003-023-05091-8

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