Article
Mutation in a short-chain collagen gene, CTRP5, results in extracellular deposit formation in late-onset retinal degeneration: a genetic model for age-related macular degeneration.
Human molecular genetics - 15 Oct 2003
Hayward Caroline, Shu Xinhua, Cideciyan Artur V, Lennon Alan, Barran Perdita, Zareparsi Sepideh, Sawyer Lindsay, Hendry Grace, Dhillon Baljean, Milam Ann H, Luthert Philip J, Swaroop Anand, Hastie Nicholas D, Jacobson Samuel G, Wright Alan F
Abstract excerpt
A primary feature of age-related macular degeneration (AMD) is the presence of extracellular deposits between the retinal pigment epithelium (RPE) and underlying Bruch's membrane, leading to RPE dysfunction, photoreceptor death and severe visual loss. AMD accounts for about 50% of blind registrations in Western countries and is a common, genetically complex disorder. Very little is known regarding its molecular...
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