Article
Late-onset macular degeneration and long anterior lens zonules result from a CTRP5 gene mutation.
Investigative ophthalmology & visual science - 1 Sept 2005
Ayyagari Radha, Mandal Md Nawajes A, Karoukis Athanasios J, Chen Lianchun, McLaren Ning C, Lichter Mona, Wong David T, Hitchcock Peter F, Caruso Rafael C, Moroi Sayoko E, Maumenee Irene H, Sieving Paul A
Abstract excerpt
PURPOSE: To identify the gene responsible for a complex ocular phenotype of late-onset macular degeneration, long anterior zonules (LAZ), and elevated intraocular pressure (IOP) and to study its expression. METHODS: Ocular examination, visual field, fluorescein angiography, and electrophysiology testing were performed. One affected individual was treated with vitamin A. DNA from 55 family members (UM:H389) was...
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