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Distinguishing happiness and meaning in life from depressive symptoms: A GWAS-by-subtraction study in the UK Biobank.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2024

de Vries Lianne P, Demange Perline A, Baselmans Bart M L, Vinkers Christiaan H, Pelt Dirk H M, Bartels Meike

Abstract excerpt

Hedonic (happiness) and eudaimonic (meaning in life) well-being are negatively related to depressive symptoms. Genetic variants play a role in this association, reflected in substantial genetic correlations. We investigated the overlap and differences between well-being and depressive symptoms, using results of Genome-Wide Association studies (GWAS) in UK Biobank. Subtracting GWAS summary statistics of depressive...

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PMID: 37435841
DOI: 10.1002/ajmg.b.32954

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