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Phenotypic and genetic analysis of a wellbeing factor score in the UK Biobank and the impact of childhood maltreatment and psychiatric illness.

Translational psychiatry - 19 Mar 2022

Jamshidi Javad, Schofield Peter R, Gatt Justine M, Fullerton Janice M

Abstract excerpt

Wellbeing is an important aspect of mental health that is moderately heritable. Specific wellbeing-related variants have been identified via GWAS meta-analysis of individual questionnaire items. However, a multi-item within-subject index score has potential to capture greater heritability, enabling improved delineation of genetic and phenotypic relationships across traits and exposures that are not possible on...

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PMID: 35304435
DOI: 10.1038/s41398-022-01874-5
PMCID: PMC8933416

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