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CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma

8 Jul 2023

Abstract excerpt

BACKGROUND: The present study aimed to identify indispensable genes associated with tumor cell viability according to the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) datasets, which may support new therapeutic targets for patients with osteosarcoma. METHODS: The transcriptome patterns between tumor and normal tissues, which were obtained from the...

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PMID: 37421290
DOI: 10.1002/jgm.3563

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