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Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification

12 Aug 2022

Abstract excerpt

BACKGROUND: Osteosarcoma is one of the most malignant tumors, and it occurs mostly in children and adolescents. Currently, surgery and chemotherapy are the main treatments. The recurrence rate is high and the prognosis is often poor. Finding an effective target gene therapy for osteosarcoma may effectively improve its prognosis. METHOD: In this study, genes essential for the survival of osteosarcoma cells were...

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PMID: 35962451
DOI: 10.1186/s12967-022-03571-9

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