Mass-spectrometric analysis of APOB polymorphism rs1042031 (G/T) and its influence on serum proteome of coronary artery disease patients: genetic-derived proteomics consequences.

doi:10.1007/s11010-023-04797-x

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Mass-spectrometric analysis of APOB polymorphism rs1042031 (G/T) and its influence on serum proteome of coronary artery disease patients: genetic-derived proteomics consequences.

Molecular and cellular biochemistry - 1 Jun 2024

Zafar Muneeza, Malik Imran Riaz, Mirza Munazza Raza, Awan Fazli Rabbi, Nawrocki Arkadiusz, Hussain Misbah, Khan Haq Nawaz, Abbas Shahid, Choudhary Muhammad Iqbal, Larsen Martin R

Abstract excerpt

Genetic polymorphisms of apolipoprotein B gene (APOB) may result into serum proteomic perturbance in Coronary Artery Disease (CAD). The current case-control cohort of Pakistani subjects was designed to analyze the genetic influence of APOB rs1042031, (G/T) genotype on serum proteome. Subjects were categorized into two groups: CAD patients (n = 480) and healthy individuals (n = 220). For genotyping, tetra ARMS-PCR...

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PMID: 37410210
DOI: 10.1007/s11010-023-04797-x

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