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Article

Evolution of a minimal cell.

Nature - 1 Aug 2023

Moger-Reischer R Z, Glass J I, Wise K S, Sun L, Bittencourt D M C, Lehmkuhl B K, Schoolmaster D R, Lynch M, Lennon J T

Abstract excerpt

Possessing only essential genes, a minimal cell can reveal mechanisms and processes that are critical for the persistence and stability of life1,2. Here we report on how an engineered minimal cell3,4 contends with the forces of evolution compared with the Mycoplasma mycoides non-minimal cell from which it was synthetically derived. Mutation rates were the highest among all reported bacteria, but were not affected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37407813
DOI: 10.1038/s41586-023-06288-x
PMCID: PMC10396959

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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