Article
Analysis for codon usage bias in membrane anchor of nonstructural protein 5A from BVDV.
Journal of basic microbiology - 1 Oct 2023
Gao Mingyang, Yang Xuanye, Wu Yuhu, Wang Jinqian, Hu Xinyan, Ma Zhongren, Zhou Jian-Hua
Abstract excerpt
The nonstructural protein 5A (NS5A) of the bovine viral diarrhea virus (BVDV) is a monotopic membrane protein. This protein can anchor to the cell membrane by an in-plane amphipathic ⍺-helix, which participates in the viral replication complex. In this study, the effects of synonymous codon usage pattern of NS5A and the overall transfer RNA (tRNA) abundance in cells on the formation of the in-plane membrane...
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