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Article

Immune escape facilitation by mutations of epitope residues in RdRp of SARS-CoV-2.

Journal of biomolecular structure & dynamics - 1 May 2023

Mallick Gupta Aayatti, Mandal SasthiCharan, Mandal Sukhendu, Chakrabarti Jaydeb

Abstract excerpt

Mutations drive viral evolution and genome variability that causes viruses to escape host immunity and to develop drug resistance. SARS-CoV-2 has considerably higher mutation rate. SARS-CoV-2 possesses a RNA dependent RNA polymerase (RdRp) which helps to replicate its genome. The mutation P323L in RdRp is associated with the loss of a particular epitope (321-327) from this protein. We consider the effects of...

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Identifiers

PMID: 35293850
DOI: 10.1080/07391102.2022.2051746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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