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Drug hypersensitivity and eosinophilia: The decisive role of p‐i stimulation

3 Jul 2023

Abstract excerpt

Eosinophilia is a common finding in drug hypersensitivity reactions (DHR). Its cause is unclear, as neither antigen/allergen-driven inflammation nor clonal expansion is involved. Most delayed-DHRs are due to p-i (pharmacologic interaction of drugs with immune receptors). These are off-target activities of drugs with immune receptors that result in various types of T-cell stimulation, some of which involve...

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PMID: 37395496
DOI: 10.1111/all.15795

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