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Article

Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT.

Cardiovascular research - 16 Oct 2023

Nicol Thomas, Falcone Sara, Blease Andrew, Vikhe Pratik, Civiletto Gabriele, Omairi Saleh Salman, Viscomi Carlo, Patel Ketan, Potter Paul K

Abstract excerpt

AIMS: Mitochondrial Complex I assembly (MCIA) is a multi-step process that necessitates the involvement of a variety of assembly factors and chaperones to ensure that the final active enzyme is correctly assembled. The role of the assembly factor evolutionarily conserved signalling intermediate in the toll (ECSIT) pathway was studied across various murine tissues to determine its role in this process and how this...

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PMID: 37395010
DOI: 10.1093/cvr/cvad101
PMCID: PMC10578914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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