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Article

Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients.

Haematologica - 1 Dec 2023

Stelmach Patrick, Richter Sarah, Sauer Sandra, Fabre Margarete A, Gu Muxin, Rohde Christian, Janssen Maike, Liebers Nora, Proynova Rumyana, Weinhold Niels, Raab Marc S, Goldschmidt Hartmut, Besenbeck Birgit, Pavel Petra, Laier Sascha, Trumpp Andreas, Dietrich Sascha, Vassiliou George S, Müller-Tidow Carsten

Abstract excerpt

Clonal hematopoiesis (CH) is an age-related condition driven by stem and progenitor cells harboring recurrent mutations linked to myeloid neoplasms. Currently, potential effects on hematopoiesis, stem cell function and regenerative potential under stress conditions are unknown. We performed targeted DNA sequencing of 457 hematopoietic stem cell grafts collected for autologous stem cell transplantation (ASCT) in...

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Identifiers

PMID: 37381752
DOI: 10.3324/haematol.2023.282992
PMCID: PMC10690900

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