Article
In silico resources help combat cancer drug resistance mediated by target mutations.
Drug discovery today - 1 Sept 2023
Huang Yuan-Qin, Wang Shuang, Gong Dao-Hong, Kumar Vinit, Dong Ya-Wen, Hao Ge-Fei
Abstract excerpt
Drug resistance causes catastrophic cancer treatment failures. Mutations in target proteins with altered drug binding indicate a main mechanism of cancer drug resistance (CDR). Global research has generated considerable CDR-related data and well-established knowledge bases and predictive tools. Unfortunately, these resources are fragmented and underutilized. Here, we examine computational resources for exploring...
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