Article
Detection of Nonsynonymous Single Variants in Human HLA-DRB1 Exon 2 Associated with Renal Transplant Rejection.
Medicina (Kaunas, Lithuania) - 9 Jun 2023
Hassan Mohamed M, Hussain Mohamed A, Ali Sababil S, Mahdi Mohammed A, Mohamed Nouh Saad, AbdElbagi Hanadi, Mohamed Osama, Sherif Asmaa E, Osman Wadah, Ibrahim Sabrin R M, Ghazawi Kholoud F, Miski Samar F, Mohamed Gamal A, Ashour Ahmed
Abstract excerpt
Background: HLA-DRB1 is the most polymorphic gene in the human leukocyte antigen (HLA) class II, and exon 2 is critical because it encodes antigen-binding sites. This study aimed to detect functional or marker genetic variants of HLA-DRB1 exon 2 in renal transplant recipients (acceptance and rejection) using Sanger sequencing. Methods: This hospital-based case-control study collected samples from two hospitals...
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