Article
Molecular BCR::ABL1 Quantification and ABL1 Mutation Detection as Essential Tools for the Clinical Management of Chronic Myeloid Leukemia Patients: Results from a Brazilian Single-Center Study.
International journal of molecular sciences - 14 Jun 2023
Marin Anelis Maria, Wosniaki Denise Kusma, Sanchuki Heloisa Bruna Soligo, Munhoz Eduardo Cilião, Nardin Jeanine Marie, Soares Gabriela Silva, Espinace Dhienifer Caroline, de Holanda Farias João Samuel, Veroneze Bruna, Becker Luiz Felipe, Costa Guilherme Lima, Beltrame Olair Carlos, de Oliveira Jaqueline Carvalho, Cambri Geison, Zanette Dalila Luciola, Aoki Mateus Nóbrega
Abstract excerpt
Chronic myeloid leukemia (CML) is a well-characterized oncological disease in which virtually all patients possess a translocation (9;22) that generates the tyrosine kinase BCR::ABL1 protein. This translocation represents one of the milestones in molecular oncology in terms of both diagnostic and prognostic evaluations. The molecular detection of the BCR::ABL1 transcription is a required factor for CML diagnosis,...
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