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TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance

26 Jun 2023

Abstract excerpt

Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve the efficacy of ICB therapy. Herein, using the CRISPR-Cas9-based genome-wide screening, we identified TRIM28 as one of the most significant regulators of PD-L1, a checkpoint protein, in G.C. cells. Mechanistically, TRIM28...

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PMID: 37357254
DOI: 10.1038/s41392-023-01450-3

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