Article
Whole Slide Imaging-Based Prediction of TP53 Mutations Identifies an Aggressive Disease Phenotype in Prostate Cancer.
Cancer research - 1 Sept 2023
Pizurica Marija, Larmuseau Maarten, Van der Eecken Kim, de Schaetzen van Brienen Louise, Carrillo-Perez Francisco, Isphording Simon, Lumen Nicolaas, Van Dorpe Jo, Ost Piet, Verbeke Sofie, Gevaert Olivier, Marchal Kathleen
Abstract excerpt
In prostate cancer, there is an urgent need for objective prognostic biomarkers that identify the metastatic potential of a tumor at an early stage. While recent analyses indicated TP53 mutations as candidate biomarkers, molecular profiling in a clinical setting is complicated by tumor heterogeneity. Deep learning models that predict the spatial presence of TP53 mutations in whole slide images (WSI) offer the...
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