Article
Deciphering the role of zingiber officinale phytochemicals for the treatment of prostate cancer: Interactions of phytochemicals with androgen receptor prostate cancer mutant H874Y ligand binding domain.
Urologic oncology - 1 Dec 2025
Lei Guanghui, Yan Shuai, Gao Xu, Shilbayeh Sireen Abdul Rahim, Vohra Saeed, Rasheed Shahzad, Khan Salah-Ud-Din, Khan Shahanavaj
Abstract excerpt
BACKGROUND: The mutations in the Androgen Receptor (AR) known as H874Y in prostate cancer greatly influence cellular signaling and execute the cell proliferation. Phytochemicals of ginger (Zingiber officinale) extracted from methanol extract were investigated through multiple servers to identify the ADMET properties. METHODS: Our key considerations were on Gingerol and Gingerenone and their bindings with AR...
Topics
- Humans
- Zingiber officinale
- Male
- Prostatic Neoplasms
- Receptors, Androgen
- Phytochemicals
- Molecular Docking Simulation
- Catechols
- Molecular Dynamics Simulation
- Ligands