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Molecular Docking, Pharmacokinetic and Molecular Simulation Analysis of Novel Mono-Carbonyl Curcumin Analogs as L858R/T790M/C797S Mutant EGFR Inhibitors.

Chemistry & biodiversity - 1 Nov 2023

Bhandari Shashikant V, Kuthe Pranali V, Patil Shital M, Nagras Om G, Sarkate Aniket P, Chaudhari Somdatta Y, Surve Sandip V

Abstract excerpt

INTRODUCTION: Curcumin, an anticancer natural compound with multiple pharmacological activities, has a weak pharmacokinetic and instability due to diketone moiety. Curcumin's stability challenges can be overcome by removing the diketone moiety and shortening the 7-carbon chain, resulting in mono-carbonyl analogs. Cancer proliferation is caused by the activation of Epidermal Growth Factor (EGFR) pathways. Current...

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PMID: 37793119
DOI: 10.1002/cbdv.202301081

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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