Unmodified rabies mRNA vaccine elicits high cross-neutralizing antibody titers and diverse B cell memory responses

Abstract excerpt

Licensed rabies virus vaccines based on whole inactivated virus are effective in humans. However, there is a lack of detailed investigations of the elicited immune response, and whether responses can be improved using novel vaccine platforms. Here we show that two doses of a lipid nanoparticle-formulated unmodified mRNA vaccine encoding the rabies virus glycoprotein (RABV-G) induces higher levels of RABV-G...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Microbial infections and disease research
• Share to Rabies epidemiology and control
• Share to Viral Infections and Outbreaks Research